Gut microbiota modification as an option in multiple sclerosis management

Gut microbiota, epigenetic modification and colorectal cancer

Micro-organisms contain 90% of cells in human body and trillions foreign genes versus less than 30 thousand of their own. The human colon host various species of microorganisms, appraised at more than 1014 microbiota and contained of over a thousand species. Although each one's profile is separable, the relative abundance and distribution of bacterial species is the same between healthy ones, c...

Gut Microbiota and Neuropsychiatric Disorders

Disease modification in multiple sclerosis.

Simplified Pathology of NIS In MS, T cells are inappropriately activated to recognize myelin and myelin-forming cells (oligodendrocytes) as foreign which results in starting of an autoimmune process. This inappropriate immune response can cause the production of cytokines that continue to activate T cells and cause additional damage to the myelin. The first stage in the cascade leading to MS is...

Gut Microbiota and Central Nervous System Condemned to Understand Each Other: Their Role in Multiple Sclerosis

The possible relationship between microbiota and inflammatory processes has been known since the 1990’s. However, it was at the beginning of the 21st century that the role played by commensal bacteria (normal microflora, indigenous microbiota) of the gastrointestinal tract in immunomodulating phenomena began to be examined, and, therefore, its effects on the pathogenesis of chronic inflammation...

Associations between the gut microbiota and host immune markers in pediatric multiple sclerosis and controls

BACKGROUND As little is known of association(s) between gut microbiota profiles and host immunological markers, we explored these in children with and without multiple sclerosis (MS). METHODS Children ≤18 years provided stool and blood. MS cases were within 2-years of onset. Fecal 16S rRNA gene profiles were generated on an Illumina Miseq platform. Peripheral blood mononuclear cells were isol...